By Honghui Zhou,Frank-Peter Theil
With an emphasis at the basic and useful facets of ADME for healing proteins, this booklet is helping readers strategize, plan and enforce translational learn for biologic drugs.
• Details state of the art ADME (absorption, distribution, metabolism and excretion) and PKPD (pharmacokinetic / pharmacodynamics) modeling for biologic drugs
• Combines theoretical with functional facets of ADME in biologic drug discovery and improvement and compares innovator biologics with biosimilar biologics and small molecules with biologics, giving a lessons-learned viewpoint
• Includes case reports approximately leveraging ADME to enhance biologics drug improvement for monoclonal antibodies, fusion proteins, pegylated proteins, ADCs, bispecifics, and vaccines
• Presents regulatory expectancies and views for constructing biologic medications in united states, ecu, and Japan
• Provides mechanistic perception into biodistribution and target-driven pharmacokinetics in very important websites of motion resembling tumors and the brain
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Extra resources for ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development
ADME and Translational Pharmacokinetics / Pharmacodynamics of Therapeutic Proteins: Applications in Drug Discovery and Development by Honghui Zhou,Frank-Peter Theil